连续性肾替代治疗抗菌药物剂量调整专家共识（2024年版）

·158·中华肾脏病杂志2024年2月第40卷第2期Chin J Nephrol.February2024,Val.40.No.2·专家共识·连续性肾替代治疗抗菌药物剂量调整专家共识(2024年版)连续性肾替代治疗抗菌药物剂量调整共识专家组中国药学会医院药学专业委员会中国医药教育协会感染疾病专业委员会通信作者：卢晓阳，浙江大学医学院附属第一医院临床药学部，杭州310003，Email:luxiaoyang(@ju.edu.cn;蔡洪流，浙江大学医学院附属第一医院重症医学科，杭州310003，Email:1193001@zju.edu.cn【摘要】连续性肾替代治疗(continuous renal replacement therapy,CRRT)是临床危重症患者重要的治疗手段。危重症患者常常需要同时接受抗菌药物和CRRT治疗。在CRRT期间，抗菌药物的药代动力学和药效学均可能受到影响，目前尚缺乏CRRT期间抗菌药物治疗剂量的推荐和建议。国内临床医学、药学、重症医学以及感染病学专家成立CRRT抗菌药物剂量调整共识专家组，围绕CRRT因素、药物特性、患者因素及CRRT期间各类抗菌药物使用基本原则进行证据检索，并充分讨论，制定了该共识，以期为CRRT期间合理使用抗菌药物提供指导建议。【关键词】连续性肾替代疗法；危重症护理；抗微生物药物管理；剂量调整；专家共识Expert consensus on antimicrobial dosing optimization during continuous renal replacementtherapy (2024)Expert group of antimicrobial dosing optimization during continuous renal replacement therapy,Chinese Pharmaceutical Association Hospital Pharmacy Professional Committee,Infectious DiseasesSociety of ChinaCorresponding author:Lu Xiaoyang,Department of Clinical Pharmacy,the First Affiliated Hospital ofZhejiang University,Hangzhou 310003,China,Email luxiaoyang@zju.edu.cn;Cai Hongliu,Departmentof Critical Care Medicine,the First Affiliated Hospital of Zhejiang University,Hangzhou 310003,China,Email:1193001@zju.edu.cnAbstract Continuous renal replacement therapy (CRRT)is an important treatment forcritically ill patients.Critically ill patients often need to receive antimicrobials and CRRT treatmentsat the same time.CRRT affects the pharmacokinetics and pharmacodynamics of antimicrobials,andthere is a lack of recommendations and suggestions for the antimicrobial dosing during CRRT.Theclinical medicine,pharmacy,intensive care and infectious diseases specialists in China set up anexpert group on antimicrobial dosing optimization during CRRT,conducted evidence search aroundCRRT factors,drug characteristics,patient factors and antimicrobial dosing optimization duringCRRT,and fully discussed and formulated the consensus,to provide guiding advices on the rationaluse of antimicrobials during CRRT.Key words Continuous renal replacement therapy;Critical care nursing;Antimicrobial stewardship;Dose adjustment;Expert consensusD01:10.3760/cma.j.cn441217-20230906-00906收稿日期2023-09-06本文编辑彭苗引用本文：连续性肾替代治疗抗菌药物剂量调整共识专家组，中国药学会医院药学专业委员会，中国医药教育协会感染疾病专业委员会，连续性肾替代治疗抗菌药物剂量调整专家共识(2024年版).中华肾脏病杂志，2024,40(2158-174.D0L:10.3760/cmaj.cm441217-20230906-00906.