肝移植术后急性移植物抗宿主病诊疗中国专家共识（2024版）

中华消化外科杂志2024年7月第23卷第7期Chin J Dig Surg.Jly2024.Val.23.N0.7·883·指南与共识·肝移植术后急性移植物抗宿主病诊疗中国专家共识(2024版)中华医学会器官移植学分会中国医师协会器官移植医师分会通信作者：吕国悦，吉林大学第一医院，长春13002l,Email:v@jlu.edu.cn;周俭，上海复旦大学附属中山医院，上海200032，Email:zhou.jian@zs-hospital..sh.cn;徐骁，杭州医学院附属人民医院，杭州310014，Email::zjxu@zju.edu.cn;杨扬，中山大学附属第三医院，广州510630，Email:yysysuc@l63.com;朱志军，首都医科大学附属北京友谊医院，北京100050，Email:zhu-zhijun@outlook.com【摘要】肝移植术后移植物抗宿主病(GVHD)是一种罕见但致命的并发症，发病率<1%，病死率高达85%。GVHD的发生是因供者T淋巴细胞对受者组织产生的细胞免疫反应，可累及皮肤、胃肠道和骨髓，典型临床表现包括皮疹、发热、腹泻和全血细胞减少。中华医学会器官移植学分会和中国医师协会器官移植医师分会组织行业内专家制订《肝移植术后急性移植物抗宿主病诊疗中国专家共识(2024版)》，对GVHD的发病机制、危险因素、临床表现、诊断及治疗进行详细阐述，旨在规范与优化肝移植术后GVHD的临床诊断与治疗，并提出诊断流程和治疗建议，以期改善肝移植术后GVHD受者预后。【关键词】肝移植：急性移植物抗宿主病：诊断：治疗：共识基金项目：国家自然科学基金(82241223、U20A20360)Chinese expert consensus on the diagnosis and treatment of acute graft-versus-host diseaseafter liver transplantation(2024 edition)Branch of Organ Transplant of China Medical Association,Branch of Organ Transplant Physicians ofChinese Medical Doctor AssociationCorresponding authors:Lyu Guoyue,First Hospital of Jilin University,Changchun 130021,China,Email:lvgy@jlu.edu.cn;Zhou Jian,Zhongshan Hospital,Fudan University,Shanghai 200032,China,Email:zhou.jian@zs-hospitalsh.cn;Xu Xiao,People's Hospital of Hangzhou Medical College,Hangzhou 310014,China,Email:zjxu@zju.edu.cn;Yang Yang,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou510630,China,Email:yysysu@163.com;Zhu Zhijun,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China,Email:zhu-zhijun@outlook.com[Abstract)Graft-versus-host disease (GVHD)after liver transplantation is a rare but fatalcomplication,with the incidence rate <1%and mortality of 85%.The occurrence of GVHD is due tothe cellular immune response of donor T lymphocytes to recipient tissues,which can affect the skin,gastrointestinal tract,and bone marrow.The typical clinical manifestations of GVHD include rash,fever,diarrhea,and decreased whole blood cells.The Branch of Organ Transplant of China MedicalAssociation,combined with Branch of Organ Transplant Physicians of Chinese Medical Doctor Associa-tion organize experts to develop the Chinese Expert Consensus On The Diagnosis And Treatment OfAcute Graft-Versus-Host Disease After Liver Transplantation (2024 edition),which elaborates on thepathogenesis,risk factors,clinical manifestations,diagnosis and treatment of GVHD.The aim is toD01:10.3760/cma.j.cm115610-20240527-00265收稿日期2024-05-27引用本文：中华医学会器官移植学分会，中国医师协会器官移植医师分会.肝移植术后急性移植物抗宿主病诊疗中国专家共识(2024版)[.中华消化外科杂志，2024,23(7883-894.D0L:10.3760cma.j.cnl15610-20240527-00265.