中国肝癌肝移植临床实践指南（2021版）

中华消化外科杂志2022年4月第21卷第4期Chin J Dig Surg,April2022.Val.21,No.4·433·指南与共识中国肝癌肝移植临床实践指南(2021版)中国医师协会器官移植医师分会中华医学会器官移植学分会肝移植学组通信作者：郑树森，'浙江大学医学院附属第一医院肝胆胰外科，杭州310003：2树兰（杭州）医院肝胆胰外科，杭州310022，Email:zyzss(@ju.edu.cn;徐骁，浙江大学医学院附属杭州市第一人民医院肝胆胰外科，杭州310006，Email:zjxu@zju.edu.cm【摘要】肝细胞癌（以下简称肝癌）是最常见的原发性肝脏恶性肿瘤，据统计我国每年>30万人死于肝癌。肝移植是全世界公认的治疗终末期肝病最有效的手段之一。我国自20世纪90年代起肝移植事业发展迅猛，在移植数量和质量方面均已达到西方发达国家水平。我国由于乙型病毒性肝炎(以下简称乙肝)流行，乙肝肝癌肝移植占比远高于西方国家。为指导全国肝癌肝移植工作更规范、有效、安全地开展，中国医师协会器官移植医师分会等组织专家制订《中国肝癌肝移植临床实践指南(2014版)》，重点阐述肝移植受者选择标准、术前降期治疗、抗病毒治疗、免疫抑制剂应用和术后复发防治5部分内容，并于2018年更新。现再次更新为《中国肝癌肝移植临床实践指南(2021版)》，以适应我国肝癌肝移植发展面临的新形势和新桃战。【关键词】肝移植；肝细胞癌；临床实践指南；指南；2021版基金项目：国家自然科学基金重点项目(81930016)：国家自然科学基金重大研究计划(92159202)：浙江省重点研发计划(2019C03050):十四五国家重点研发计划(2021YFA1100504):浙江省“尖兵”“领雁”研发攻关计划(2022C03108)Chinese clinical practice guidelines on liver transplantation for hepatocellular carcinoma (2021edition)Chinese College of Transplant Doctors,Liver Transplantation Group,Chinese Society of Organ Trans-plantation,Chinese Medical AssociationCorresponding authors:Zheng Shusen,'Department of Hepatobiliary and Pancreatic Surgery,the FirstAffiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;'Department ofHepatobiliary and Pancreatic Surgery,Shulan (Hangzhou)Hospital,Hangzhou 310022,China,Email:zyzss@zju.edu.cn;Xu Xiao,Department of Hepatobiliary and Pancreatic Surgery,the Affiliated HangzhouFirst People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,Email:zixu@zju.edu.cnAbstract Hepatocellular carcinoma (HCC)is the most common primary liver cancer andover 300,000 people in China die of HCC each year Liver transplantation (LT)is generally reco-gnized as one of the most effective therapeutic approaches for end-stage liver diseases.Since thebeginning of the 1990s,LT in China has been developed rapidly,and it has reached the level of deve-loped countries in terms of quantity and quality.Due to the prevalence of hepatitis B virus (HBV)inChina,the proportion of LT for HBV-related HCC is much higher than that in the Western countries.In order to develop an effective,safe,and standardized protocol to guide the national practice of LTfor HCC,the Chinese clinical practice guideline on liver transplantation for hepatocellular carcinoma(2014 edition)was compiled by experts from the Chinese College of Transplant Doctors,et al.Theguideline covers the following aspects of criteria for LT in HCC patients,preoperative downstagingtreatment,anti-hepatitis viral therapy,application of immuno-suppressants and prevention andD01:10.3760/cma.j.cm115610-20220316-00135收稿日期2022-03-16引用本文：中国医师协会器官移植医师分会，中华医学会器官移植学分会肝移植学组.中国肝癌肝移植临床实践指南(2021版)01.中华消化外科杂志，2022,21(4433-443.D0L:10.3760/cma.jcn115610-20220316-00135