反复妊娠丢失的男性因素评估与管理中国专家共识

中华生殖与避孕妹志2023年3月第43卷第3期Chin J Reprod Contracep.Mare小2023.Val.43No.3·219·规范与标准。反复妊娠丢失的男性因素评估与管理中国专家共识中国医师协会生殖医学专业委员会生殖男科学组反复妊级丢失的男性因素评估与管理中国专家共识编写组道信作者：熊承良，Email:clxiong951@sina.com,电话：+86-27-82742288；康跃凡，Email:fkyf@163.com,电话：+86-591-87556044；唐运苹，Email:tyg813@126.com,电话：+86-20-87696536【摘要】反复妊娠丢失(recurrent pregnancy loss,RPL)是一种临床常见的生有问题，其病因较为复杂，是一个涉及多种因素的疾病。近年来随着研究的不断深入，越来越多的证据证明男性因素在其发生过程中同样发挥着不容忽视的作用。鉴于此，中国医师协会生殖医学专业委员会生殖男科学组组织了生殖男科领域的专家，从染色体异常、精液参数、精子非整倍性以及一些基因的多态性和精子的表观遗传等方面的评估和临床管理进行了深入地探讨。推荐针对RPL夫妇中的男性也进行染色体核型分析，并合理选择胚胎植入前遗传学检测等：建议进行精子DNA碎片率检测，并依据病因进行适当的干预；建议可以考虑进行精子的单倍体检测等进一步探索RPL中男性因素等。本共识可为从事生殖医学、男科学的专业医务人员提供建议。【关键词】反复妊娠丢失；男性因素；评估；临床管理；专家共识基金项目：国家重点研发计划(2018YFC1004601):国家科技支撑计划(2012BAI32B03):湖北省重点研发计划(2022BCA042)101指南注册：国际实践指南注册与透明化平台，IPGRP-2022CN334Chinese expert consensus on the assessment and management of male factors in recurrentpregnancy lossChinese Expert Consensus Compilation Group for Assessment and Management of Male Factors inRecurrent Pregnancy Loss,Reproductive Andrology Group,Reproductive Medicine ProfessionalCommittee of Chinese Medical Doctor AssociationCorresponding authors:Xiong Chengliang,Email:clxiong951@sina.com,Tel:+86-27-82742288;Kang Yuefan,Email fikyf@163.com,Tel:+86-591-87556044;Tang Yunge,Email:tyg813@126.com,Tel+86-20-87696536Abstract Recurrent pregnancy loss (RPL)is one of the common clinical fertilityproblems,which is a complex disease involving many factors with diverse causes.With thedeepening of research in recent years,increasing evidence has also established that male factors alsoplay a crucial role in RPL Therefore,the Reproductive Andrology Group of the ProfessionalCommittee of Reproductive Medicine of the Chinese Medical Doctor Association organized experts inthe field of reproductive andrology to conduct in-depth discussion on the assessment and clinicalmanagement of male factors,including chromosomal abnormalities,semen parameters,spermaneuploidy,polymorphisms of some genes and epigenetic inheritance of sperm,etc.It isrecommended to perform karyotype analysis for male of RPL couples,and to choose preimplantationD01:10.3760/cma.j.cm101441-20220813-00344收稿日期2022-08-15本文编辑王李艳引用本文：中国医师协会生殖医学专业委员会生殖男科学组反复妊娠丢失的男性因素评估与管理中国专家共识编写组.反复妊娠丢失的男性因素评估与管理中国专家共识】.中华生殖与避孕杂志，2023,43(3219-225.D0L:10.3760/cma.j.cn101441-20220813-00344.