醛代谢紊乱学说指导急危重症早期救治中国专家共识（2023）

6中华危重病急救医学2024年1月第36卷第1期Chin Crit Care Med,January2024.Vol36.No.l·专家共识·醛代谢紊乱学说指导急危重症早期救治中国专家共识（2023)中华医学会急诊医学分会中国医疗保健国际交流促进会胸痛学分会山东省医学会心肺复苏与体外生命支持多学科联合委员会《醛代谢紊乱学说指导急危重症早期救治中国专家共识(2023)》专家组通信作者：陈玉国，山东大学齐鲁医院急珍科，济南250012，Email:chen919085@sdu.edu.cn;徐峰，山东大学齐鲁医院急诊科，济南250012，Email:xufengsdu(@126.com【摘要】急危重症疾病具有突发性、复杂性、不可预测性的特点，可使患者迅速出现休克或多器官功能衰竭等严重不良预后。目前已经证实，醛代谢紊乱导致大量醛类物质蓄积，毒性醛损伤细胞、组织，造成器官功能障碍的共性机制存在于多种急危重症疾病中。但目前针对醛代谢紊乱这一新学说的定义、醛类物质的检测方法及醛代谢系乱学说指导急危重症早期救治的应用，尚未系统化、规范化。为此，中华医学会急诊医学分会、中国医疗保健国际交流促进会胸痛学分会、山东省医学会心肺复苏与体外生命支持多学科联合委员会组织国内急危重症医学、药学、分子化学等多学科专家，全面回顾有关醛代谢紊乱对急危重症早期各疾病发病机制影响的国内外基础和临床研究，共同制定了《醛代谢奈乱学说指导急危重症早期救治中国专家共识(2023)》，旨在通过醛代谢素乱这一共性、基础新学说的指导，从新的层面进一步提高急危重症患者救治水平，进而为急危重症患者制定新的、安全可靠的救治方案，提高急危重症患者总体生存率。【关键词】醛代谢紊乱；急危重症；醛脱氢酶2；专家共识基金项目：国家自然科学基金(82030059)：山东省重点研发计划项目(2021ZLGX02):泰山学者攀登计划专家建设工程专项(tspd20181220)实践指南注册：国际实践指南注册与透明化平台，PREPARE-2023CN810D0I:10.3760/cma.j.cn121430-20231201-01026Chinese experts consensus on aldehyde metabolism disorder guided the early management of emergency andcritical care medicine (2023)Chinese Society of Emergency Medicine,Chest Pain Branch of China International Exchange and Promotive Associationfor Medical and Health Care,Multidisciplinary Joint Committee on Cardiopulmonary Resuscitation and ExtracorporealLife Support of Shandong Medical Association,Workgroup of the Chinese Experts Consensus on Aldehyde MetabolismDisorder Guided the Farly Management of Emergency and Critical Care Medicine(2023)Corresponding author:Chen Yuguo,Qilu Hospital of Shandong Unirersity,Jinan 250012,Shandong,China,Emailchen919085@sdu.edu.cn;Xu Feng.Qilu Hospital of Shandong University,Jinan 250012,Shandong,China,Emailxufengsdu@126.com[Abstract]Emergency and critical diseases is characterized by suddenness,complexity and unpredictability,which can lead to severe adverse prognosis such as shock or multiple organ failure.It has been confirmed that thecommon mechanism of aldehyde metabolism disorder leading to the accumulation of a large number of aldehydes,injury of cells and tissues caused by toxic aldehydes,and organ dysfunction existed in various emergency and criticaldiseases.However,the definition of the theory of aldehyde metabolism disorder,the detection methods of aldehydes,andthe application of the theory of aldehyde metabolism disorder in guiding the early treatment of emergency and criticaldiseases have not been systematized and standardized.Therefore,Chinese Society of Emergency Medicine,Chest PainBranch of China International Exchange and Promotive Association for Medical and Health Care,and MultidisciplinaryJoint Committee on Cardiopulmonary Resuscitation and Extracorporeal Life Support of Shandong Medical Associationorganized multidisciplinary experts in emergency and critical care medicine,pharmacy,and molecular chemistry,etc.,tocomprehensively review the basic and clinical research on the effect of aldehyde metabolism disorder in the early stageof emergency and critical diseases at home and abroad,and jointly formulated the Chinese