人工肝血液净化系统治疗细胞因子风暴综合征专家共识

·14中生临床感垫病杂志2024年2月第17第1期Chin】Clin Infeet Dis.February2024.Val.17.Na.1·指南与共识·人工肝血液净化系统治疗细胞因子风暴综合征专家共识中华医学会感染病学分会肝衰竭与人工肝学组传染病重症诊治全国重点实验室国家传染病医学中心通信作者：李兰娟，浙江大学医学院附属第一医院传染病重症诊治全国重点实验室，国家感染性疾病临床医学研究中心，感染性疾病协同创新中心，杭州310003，Email:ljli@zju.edu.cn【摘要】细胞因子风暴综合征(cytokine storm syndrome,CSS)是一种由感染、肿瘤和自身免疫性疾病等病因引起的免疫反应失控的临床综合征。患者主要表现为血浆中细胞因子水平明显升高，并出现发热、全身多个系统或脏器发生炎症反应及功能损害，甚至衰竭而死亡。人工肝血液净化系统治疗能清除炎症因子，减轻炎症反应对机体的损伤，其在重症H7N9、重型/危重型新型冠状病毒感染患者临床救治中具有重要应用价值。专家组在《人工肝血液净化系统应用于重型、危重型新型冠状病毒肺炎治疗的专家共识》基黜上，结合现有临床应用经验及国内外研究进展，针对人工肝血液净化系统治疗CS$患者的基本原理、治疗适应证、相对禁忌证、治疗模式选择、监测指标及疗效评价等进行总结，制订了本专家共识，供临床医护人员参考。【关键词】人工肝；血液净化；细胞因子风暴；共识基金项目：国家重点研发计划(2021YF℃2301805)D01:10.3760/cma.j.issn.1674-2397.2024.01.002Expert consensus on the artificial liver blood purification system in treatment of cytokine stormsyndromeLiver Failure and Artificial Liver Group.Chinese Society of Infectious Diseases.Chinese Medical Association;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases;National Medical Center forInfectious DiseasesCorresponding author:Li Lanjuan,the First Affiliated Hospital,Zhejiang Unirersity School of Medicine,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases.National Clinical Research Centerfor Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Hangzhou 310003,China,Email:lii@zju.edu.en[Abstract]Cytokine storm syndrome (CSS)is a clinical syndrome characterized by uncontrolledimmune reaction caused by infection,tumor or autoimmune diseases.It is mainly manifested by significantlyelevated plasma cytokines levels,leading to fever,inflammation and functional damage in multiple systems ororgans,and even death due to organ failure.The artificial liver blood purification system can effectivelyremove inflammatory factors and alleviate the damage of inflammation in CSS.It has important clinicalapplication value in the treatment of severe H7N9 and severe/critical COVID-19 patients.Based on the Expertconsensus on the application of artificial liver blood purification system in the treatment of severe and criticalCOVD-19,combined with clinical experiences,and domestic and foreign research progress,this expertconsensus summarizes the basic principles,indications for treatment,relative contraindications,selection oftreatment modes,monitoring indicators,and evaluation of efficacy of artificial liver blood purification systemin the treatment of CSS patients.to provide reference for clinical application.[Key words]Artificial liver;Blood purification;Cytokine storm;Consensus引用格式：中华医学会感染病学分会肝衰竭与人工肝学组，传染病重症诊治全国重点实验室，国家传染病医学中心.人工肝血液净化系统治疗细胞因子风暴综合征专家共识[J].中华临床感染病杂志，2024.17(1)：1422D01:10.3760ema.j.issn.1674-2397.2024.01.002.